| 药品名称 | Pranlukast |
|---|---|
| 分子靶点 | C-X-C chemokine receptor type 4 |
| 酶 | Cytochrome P450 3A4;Cytochrome P450 2C9 |
| 药物类型 | Small Molecule |
| 研发阶段 | Investigational |
| 药物描述 | Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens. |
| 结构式 |
 |
| 药物别名 | Pranlukast |
| 治疗类别 | Agents to Treat Airway Disease;Anti-Asthmatic Agents;Benzopyrans;Cytochrome P-450 CYP2C9 Inhibitors;Cytochrome P-450 CYP3A Substrates;Cytochrome P-450 CYP3A4 Substrates;Cytochrome P-450 Enzyme Inhibitors;Drugs for Obstructive Airway Diseases;Hormone Antagonists;Hormones, Hormone Substitutes, and Hormone Antagonists;Leukotriene Antagonists;Pyrans;Respiratory System Agents |
| UNII号 | TB8Z891092 |
| CAS号 | 103177-37-3 |
| 分子量 | 481.512 |
| 分子式 | C27H23N5O4 |
| 适应症 | Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. |
| 药效学 | Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. |
| 作用机制 | Pranlukast selectively antagonizes leukotriene D (LTD) at the cysteinyl leukotriene receptor, CysLT, in the human airway. Pranlukast inhibits the actions of LTD at the CysLT receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. |
| 代谢 | Hepatic |
| 毒理 | Side effects include headache, abdominal or stomach pain, cough, dental pain, dizziness, fever, heartburn, skin rash, stuffy nose, weakness or unusual tiredness. |
| ATC代码 | R03DC02 |
Pranlukast靶点信息
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