| 药品名称 |
Isopropamide
|
| 分子靶点 |
Muscarinic acetylcholine receptor M3;Muscarinic acetylcholine receptor M4
|
| 药物类型 |
Small Molecule
|
| 研发阶段 |
Approved, Vet approved
|
| 药物描述 |
Isopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
|
| 结构式 |
 |
| 药物别名 |
Isopropamide
|
| 治疗类别 |
Agents producing tachycardia;Alimentary Tract and Metabolism;Amines;Ammonium Compounds;Anticholinergic Agents;Drugs for Functional Gastrointestinal Disorders;Muscarinic Antagonists;Nitrogen Compounds;Onium Compounds;Synthetic Anticholinergics, Quaternary Ammonium Compounds
|
| UNII号 |
8B9I31H724
|
| CAS号 |
7492-32-2
|
| 分子量 |
353.5209
|
| 分子式 |
C23H33N2O
|
| 适应症 |
For the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis, biliary dyskinesia and chronic cholelithiasis, duodenitis, gastrointestinal spasm; it may also be used to treat genitourinary spasm.
|
| 药效学 |
Isopropamide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
|
| 作用机制 |
Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movements of smooth muscles present in the gastrointestinal tract. Inhibition here decreases acidity and motility, aiding in the treatment of gastrointestinal disorders.
|
| 毒理 |
Symptoms of overdose include dryness of mouth, dysphagia, thirst, blurred vision, dilated pupils, photophobia, fever, rapid pulse and respiration, disorientation. Depression and circulatory collapse may result from severe overdosage.
|
| ATC代码 |
A03CA01
|
