| 药品名称 | Cefroxadine |
|---|---|
| 分子靶点 | Penicillin-binding protein 1B |
| 酶 | Beta-lactamase |
| 药物类型 | Small Molecule |
| 研发阶段 | Withdrawn |
| 药物描述 | Cefroxadine is an orally available cephalosporin antibiotic. It is structurally related to cefalexin, and both drugs share a similar spectrum of activity. It was used in Italy but has since been withdrawn. |
| 结构式 |
 |
| 药物别名 | Cefroxadine;cefroxadino |
| 治疗类别 | Amides;Anti-Bacterial Agents;Antibacterials for Systemic Use;Antiinfectives for Systemic Use;Aza Compounds;Azabicyclo Compounds;beta-Lactams;Cephalexin;Cephalosporins;First-Generation Cephalosporins;Lactams;Nephrotoxic agents;Sulfur Compounds;Thiazines |
| UNII号 | B908C4MV2R |
| CAS号 | 51762-05-1 |
| 分子量 | 365.4 |
| 分子式 | C16H19N3O5S |
| 适应症 | Was used for the treatment of bacterial infections. |
| 药效学 | Cefroxadine is a cephalosporin antibiotic which produces a bactericidal effect on susceptible bacteria . |
| 作用机制 | Cefrixadine is a cephalosporin antibiotic, a class of β-lactam antibiotics similar to penicillins, which binds to and inhibits penicillin binding proteins (PBPs) . PBPs are responsible for catalyzing the transpeptidase reaction which cross-links the peptide side chains on the sugar residues of a peptidoglycan unit, adding the unit to the peptidoglycan layer. This disrupts the balance between the hydrolysis of peptidoglycan, in order to insert new peptidoglycan units, by murein hydrolase and the attachment of the new units which leads to overall destruction of the peptidoglycan layer. With the loss of its peptidoglycan layer the cell also loses its resistance to the high osmotic pressure inside its membrane and lyses. |
| 吸收 | Oral bioavailability of 90% . |
| 分布量 | Volume of distrubution of 15 L . |
| 蛋白结合 | Cefrixadine is 10% bound to human plasma proteins . |
| 排泄 | Primarily eliminated in the urine (80-96%) . |
| 半衰期 | The serum half life is 0.9-1.1 h . |
| 清除 | The total body clearance is 340 mL/min and the renal clearance is 250 mL/min . |
| ATC代码 | J01DB11 |
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