*.*.228.27
药智网药智汇药智通专利通咨询新闻大讲堂产业大脑医械数据行业报告 客户服务
药智数据APP
iOS下载 Android下载
药智数据企业版
量身打造，体验升级
立即前往
VIP免费试用申请
登录 注册
搜索
当前位置： 首页 > 反馈纠错 帮助中心
结构式搜索
佛司可林
纠错 分享
CAS号 66575-29-9
中文别名 福斯高林;毛喉萜;考福新;锦紫苏醇;腺苷酸环化酶激活剂;佛司可林, 98+%;佛司可林(标准品)
英文别名 BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE; FORSKOHLIN; FORSKOLIN; FORSKOLIN, COLEUS FORSKOHLII; COLEONOL; COLFORSIN; 7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE; 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
分子量 410.5
分子式 C22H34O7
EINECS编号 266-410-9
综合信息 查看供应
目录导航
提示：点击目录可直接跳转到对应的信息。

佛司可林物理化学性质

外观：白色粉末
鉴定方法：Mass, NMR
分析方法：HPLC-DAD or/and HPLC-ELSD
熔点 282-232 °C
沸点 520℃
密度 1.23
闪点 172℃
储存条件 −20°C
溶解度 : DMSO: 5 mg/mL stable at least 6 months at room temperature
form : powder
color : off-whiteMerck : 13,2500

佛司可林产品用途

用于含量测定、鉴定、药理实验等

佛司可林提取来源

毛喉鞘蕊花 Coleus forskohlii。草本，直立或上升，高约40厘米。茎粗壮，具四棱及四槽，分枝，被长柔毛。在上部较密。叶卵圆形，顶端钝或急尖，基部骤楔形下延成柄，边缘具圆齿，近肉质，两面密被绒毛及柔毛；叶柄长6-15毫米，密被柔毛。轮伞花序由6-10花组成，多数排列成总状花序，总状花序长约2.3-10厘米；苞片卵圆形，长约8毫米，宽约7毫米，顶端尾状急尖，边缘具缘毛，外面被微柔毛，在开花时脱落；萼钟形，长约6毫米，喉部内面密被长柔毛，5齿，后齿大，心形，顶端短尖，余4齿近三角形，先端钻状渐尖，在果时常增大且下弯；花冠紫蓝色，长约1.2-1.5厘米，外面被稀疏的腺点，花冠管向下弯，向喉部逐渐增大宽至3.5毫米，冠檐二唇形，上唇4浅裂，裂片不相等，下唇延长，长圆形，舟状；雄蕊4，内藏或稍外露，花丝在中部以下合生成鞘状；花柱外伸。小坚果圆形，压扁。花期9月。

佛司可林药理药效

具有抗高血压、抗肿瘤转移和抗青光眼等药理活性。




 

上下游产品信息



 

佛司可林安全说明书(MSDS)

类别：有毒物品
毒性分级:中毒
急性毒性:口服- 大鼠  LD50 2550  毫克/ 公斤; 口服- 小鼠 LD50: 2300 毫克/公斤
可燃性危险特性:可燃, 火场排出辛辣刺激烟雾 
灭火剂:砂土, 二氧化碳, 泡沫, 雾状水

佛司可林储运特性

储运特性 库房通风低温干燥; 与强酸, 强碱, 食品分开储运

安全术语
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36/37 Wear suitable protective clothing and gloves.
穿戴适当的防护服和手套。
风险术语
R21 Harmful in contact with skin.
与皮肤接触有害。
上游原料
3-Hydroxy-2-methyl-2-cyclohexen-1-one3-Methoxy-2-methyl-2-cyclohexen-1-one3-Methoxy-2,6,6-trimethyl-2-cyclohexen-1-one2,4,4-Trimethyl-3-vinyl-2-cyclohexen-1-one2,4,4-Trimethyl-3-vinyl-2-cyclohexen-1-ol2-Butynoic acid2,4,4-trimethyl-3-vinyl-2-cyclohexen-1-yl 2-butynoate(8aS,8bS)-3,6,6,8b-Tetramethyl-4,6,7,8,8a,8b-hexahydro-2H-naphtho[1,8-bc]furan-2-one(1S,8aS)-8-(Hydroxymethyl)-4,4,7,8a-tetramethyl-1,2,3,4,6,8a-hexahydro-1-naphthalenol(1aR,7S,7aR,7bR)-7b-(Hydroxymethyl)-1a,4,4,7a-tetramethyl-1a,2,4,5,6,7,7a,7b-octahydronaphtho[1,2-b]oxiren-7-ol(1aR,5aS,8bR,10aR)-8,8,8b,10a-Tetramethyl-4-phenyl-5a,7,8,8b,10,10a-hexahydro-6H-oxireno[2',3':7,8]naphtho[1,8-de][1,3]dioxepine(1R,2R,4R,4aR,8S,8aR)-8-(Benzyloxy)-1-(hydroxymethyl)-2,5,5,8a-tetramethyldecahydro-1,4-naphthalenediol(1R,2R,4R,4aR,8S,8aR)-8-(Benzyloxy)-1-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2,5,5,8a-tetramethyldecahydro-1,4-naphthalenediol(3R,4R,4aR,5S,8aR)-5-(Benzyloxy)-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4-hydroxy-3,4a,8,8-tetramethyloctahydro-1(2H)-naphthalenone(3R,4R,4aR,5S,8aR)-4-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-4,5-dihydroxy-3,4a,8,8-tetramethyloctahydro-1(2H)-naphthalenone(3aR,4R,6aR,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyloctahydronaphtho[1,8-de][1,3]dioxin-6(3aH)-one(3aR,6aR,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-6a,7,8,9,9a,9b-hexahydronaphtho[1,8-de][1,3]dioxin-6(3aH)-one(3aR,6aS,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-6a,7,8,9,9a,9b-hexahydronaphtho[1,8-de][1,3]dioxin-6(3aH)-oneisopropenyl methyl ether; 2-methoxy-1-propene(3aR,6R,6aS,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-3a,6,6a,7,8,9,9a,9b-octahydronaphtho[1,8-de][1,3]dioxin-6-ol(3aR,6R,6aS,9aS,9bR)-3a-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyl-3a,6,6a,7,8,9,9a,9b-octahydronaphtho[1,8-de][1,3]dioxin-6-yl N,N-dimethylcarbamate(3aS,6aS,7S,7aR,8aR,8bR,8cR)-8b-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2,2,6,6,8a,8c-hexamethyldecahydrooxireno[2',3':2,3]naphtho[1,8-de][1,3]dioxin-7-yl dimethylcarbamate(3aR,4R,5S,6S,6aS,9aS,9bR)-3a-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4,5-dihydroxy-2,2,4,7,7,9b-hexamethyldecahydronaphtho[1,8-de][1,3]dioxin-6-yl dimethylcarbamate(3aR,4R,5S,6S,6aS,9aS,9bR)-3a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-2,2,4,7,7,9b-hexamethyldecahydronaphtho[1,8-de][1,3]dioxine-4,5,6-triol(3aS,6aR,7R,7aS,10aS,10bS,10cR)-6a-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-7-hydroxy-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(3aS,6aR,7R,7aS,10aS,10bS,10cR)-7-Hydroxy-6a-(hydroxymethyl)-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(3aS,7R,7aS,10aS,10bS,10cR)-7-Hydroxy-1,1,5,5,7,10c-hexamethyl-9-oxooctahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxine-6a(1H)-carbaldehyde1-Propynyllithium(3aS,6aR,7R,7aS,10aS,10bS,10cR)-7-Hydroxy-6a-(1-hydroxy-2-butynyl)-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(3aS,6aS,7R,7aS,10aS,10bS,10cR)-6a-(2-Butynoyl)-7-hydroxy-1,1,5,5,7,10c-hexamethyldecahydro[1,3]dioxolo[4',5':3,4]naphtho[1,8-de][1,3]dioxin-9-one(4aS,7aS,7bR,10aS,10bS,13aS,13bR)-2,6,6,7b,10,10,13b-Heptamethyl-7a,8,9,10,10a,10b,13a,13b-octahydro-4H,7bH-[1,3]dioxolo[4',5':3,4]pyrano[3',2':1,2]naphtho[1,8-de][1,3]dioxine-4,12-dione(2R,4aS,7aS,7bR,10aS,10bS,13aS,13bR)-2,6,6,7b,10,10,13b-Heptamethyl-2-vinyldecahydro-4H,7bH-[1,3]dioxolo[4',5':3,4]pyrano[3',2':1,2]naphtho[1,8-de][1,3]dioxine-4,12-dione(2R,4aS,7aS,10aS,10bR,11S,12S,12aR)-11,12-Dihydroxy-2,6,6,10,10,10b,12a-heptamethyl-2-vinyldecahydro-4H,8H-pyrano[2',3':7,8]naphtho[1,8-de][1,3]dioxin-4-one(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,6,10,10b-Tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyldodecahydro-1H-benzo[f]chromen-1-one; Deacetylforskolin
下游产品
Colforsin daropate hydrochloride; Colforsin dapropate hydrochloride; Colforsin daproate hydrochloride; NKH-477; Adehl