S36
Wear suitable protective clothing.
穿戴适当的防护服。
穿戴适当的防护服。
| CAS号 | 3094-09-5 |
| 中文别名 | 5'-脱氧-5-氟尿嘧啶核苷;去氧氟尿甙;去氧氟尿苷;5’-脱氧-5-氟尿嘧啶核苷;5-脱氧氟尿苷;氟铁龙;MURINE RECOMBINANT;5-氟-5-脱氧尿苷;5‘-脱氧-5-氟尿苷;5'-去氧氟尿苷;1,2,5'-去氧氟尿苷;5'-去氧-5-氟尿苷;5-FLUORO-5锟斤拷-DEOXYURIDIN |
| 英文别名 | 5'-DEOXY-5-FLUOROURIDINE;5'-DEOXYFLUOROURIDINE;5'-DFUR;5'DFURD;(+)-5-FLUORO-5'-DEOXYURIDINE;5-FLUORO-5'-DEOXYURIDINE;DOXIFLURIDINE;RO-21-9738;5’-deoxy-5-fluoro-uridin;flutron;furtulon;Doxifluridine (furtulon);DOXIFLUIRDINE;5'-Deoxy-fluorouridine(DFUR)/Doxifluridine;(+)-5-FLUORO-5'-DEOXYURIDINE 97%;5-FLURO-5’-DEOXYURIDINE;5Urd, 5-Fluoro-5deoxyuridine;5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738;Doxifluidine;DOXIFLURIDINE(SUBJECTTOPATENTFREE)E |
| 分子量 | 246.19244 |
| 分子式 | C9H11N2O5F |
| EINECS编号 | 221-440-1 |
综合信息
查看供应
物理化学性质
外观性质：白色结晶粉末。熔点：188-192 °C
熔点:188-192 °C(lit.)
折射率:20 ° (C=1, H2O)
Merck:3437
产品用途
氟尿嘧啶类抗肿瘤药，为氟尿嘧啶的前体药物。在肿瘤组织内存在着的胸腺嘲嚏核苷磷酸化酶，对其进行作用而使其在肿瘤内转化为氟尿嘧啶，从而发挥抗肿瘤的作用。其抗肿瘤的专一性较强，毒性较低。临床用于胃癌、结肠直肠癌、乳腺癌，缓解率可达30%以上。医药中间体。
安全术语
风险术语
R36/37/38
Irritating to eyes, respiratory system and skin.
刺激眼睛、呼吸系统和皮肤。
刺激眼睛、呼吸系统和皮肤。
上游原料
(2R,3R,4R,5S)-4,5-bis(acetoxy)-2-methyltetrahydro-3-furanyl acetate5-fluoro-1,3-bis(trimethylsilyl)-2,4(1H,3H)-pyrimidinedionetrifluoromethyl (trimethylsilyl)methyl sulfone; trimethyl[[(trifluoromethyl)sulfonyl]methyl]silane(2R,3R,4R,5R)-4-(acetoxy)-2-[5-fluoro-2,4-dioxo-3-(trimethylsilyl)-3,4-dihydro-1(2H)-pyrimidinyl]-5-methyltetrahydro-3-furanyl acetate1-Methoxy-1-methylethyl methyl ether; 2,2-Dimethoxypropane1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-fluoro-2,4(1H,3H)-pyrimidinedione; 5-Fluorouridine1-[(2R,3R,4S,5S)-3,4-dihydroxy-5-(iodomethyl)tetrahydro-2-furanyl]-5-fluoro-2,4(1H,3H)-pyrimidinedione2',3'-Isopropylidene-5-fluorouridine; 5-Fluoro-1-[(4R,6R)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-2,4(1H,3H)-pyrimidinedione5-Fluoro-1-[(4R,6S)-6-(iodomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-2,4(1H,3H)-pyrimidinedione; 5'-Deoxy-5'-iodo-2',3'-isopropylidene-5-fluorouridine5'-Deoxy-2',3'-isopropylidene-5-fluorouridine; 5-Fluoro-1-[(4R,6R)-2,2,6-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-2,4(1H,3H)-pyrimidinedione
