上游原料
(2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3-furanol(2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-[(trityloxy)methyl]tetrahydro-3-furanol[(2R,3R,4S)-5-(acetoxy)-4-fluoro-3-[(1-hydroxyvinyl)oxy]tetrahydro-2-furanyl]methyl benzoate[(2R,3R,4S)-3-(acetoxy)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl benzoate6-Chloropurine; 6-chloro-9H-purine[(2R,3R,4S,5R)-3-(acetoxy)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl benzoate(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydro-3-furanol(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4-fluorotetrahydro-3-furanolO-[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-2-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4-fluorotetrahydro-3-furanyl] O-phenyl carbonothioate9-[(2R,3S,5S)-5-([[tert-butyl(dimethyl)silyl]oxy]methyl)-3-fluorotetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,3S,5S)-5-([[tert-butyl(dimethyl)silyl]oxy]methyl)-3-fluorotetrahydro-2-furanyl]-9H-purin-6-amine6-Chloropurine; 6-chloro-9H-purine[(2R,3R,4S,5R)-3,5-bis(benzoyloxy)-4-fluorotetrahydro-2-furanyl]methyl benzoate(2R,3R,4S)-5-bromo-4-fluoro-2-(hydroxymethyl)tetrahydro-3-furanol(2R,3R,4S,5R)-4-fluoro-2-(hydroxymethyl)-5-methoxytetrahydro-3-furanol[(2R,3R,4S,5R)-4-fluoro-3-hydroxy-5-methoxytetrahydro-2-furanyl]methyl benzoate((2R,3R,4S,5R)-4-fluoro-5-methoxy-3-[[(methylsulfanyl)carbothioyl]oxy]tetrahydro-2-furanyl)methyl benzoate[(2S,4S,5R)-4-fluoro-5-methoxytetrahydro-2-furanyl]methyl benzoate[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl benzoate[(2R,3S,4S,5R)-4-(acetoxy)-5-(6-amino-9H-purin-9-yl)-3-bromotetrahydro-2-furanyl]methyl acetate[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-3-bromo-4-hydroxytetrahydro-2-furanyl]methyl acetate[(2S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydro-2-furanyl]methyl acetate[(2S,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl acetate6-Chloropurine; 6-chloro-9H-purine(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydro-3-furanol[(2R,3R,4S,5R)-3,5-bis(benzoyloxy)-4-fluorotetrahydro-2-furanyl]methyl benzoate[(2R,3R,4S,5R)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl benzoate[(2R,3R,4S,5R)-3-(benzoyloxy)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl benzoate(2R,3R,4S,5R)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-4-fluoro-5-methoxytetrahydro-3-furanolO-[(2R,3R,4S,5R)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-4-fluoro-5-methoxytetrahydro-3-furanyl] S-methyl carbonodithioatetert-butyl(diphenyl)silyl [(2S,4S,5R)-4-fluoro-5-methoxytetrahydro-2-furanyl]methyl ether; tert-butyl[[(2S,4S,5R)-4-fluoro-5-methoxytetrahydro-2-furanyl]methoxy]diphenylsilane[[(2S,4S)-5-bromo-4-fluorotetrahydro-2-furanyl]methoxy](tert-butyl)diphenylsilane; [(2S,4S)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl tert-butyl(diphenyl)silyl ethertert-butyl(diphenyl)silyl [(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl ether; 9-[(2R,3S,5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3-fluorotetrahydro-2-furanyl]-6-chloro-9H-purine[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methanol9H-Purin-6-amine; 9H-Purin-6-ylamine; Adenine(2S,3R,4S,5R)-2-methoxy-5-[[(4-methoxybenzyl)oxy]methyl]-4-[(methylsulfonyl)oxy]tetrahydro-3-furanyl methanesulfonate(2S,3R,5S)-2-methoxy-5-[[(4-methoxybenzyl)oxy]methyl]tetrahydro-3-furanol(2S,3S,5S)-3-fluoro-5-[[(4-methoxybenzyl)oxy]methyl]tetrahydro-2-furanyl methyl ether; (2S,3S,5S)-3-fluoro-2-methoxy-5-[[(4-methoxybenzyl)oxy]methyl]tetrahydrofuran9-((2R,3S,5S)-3-fluoro-5-[[(4-methoxybenzyl)oxy]methyl]tetrahydro-2-furanyl)-9H-purin-6-amine; 9-((2R,3S,5S)-3-fluoro-5-[[(4-methoxybenzyl)oxy]methyl]tetrahydro-2-furanyl)-9H-purin-6-ylamine(3aR,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-olp-Toluoyl chloride; 4-methylbenzoyl chloride[(3aR,4R,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzoate[(3aR,4R,6S,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzoate[(2R,3S,4R,5S)-3,4-dihydroxy-5-methoxytetrahydro-2-furanyl]methyl 4-methylbenzoate[(3aR,4R,6S,6aR)-6-methoxy-2,2-dioxotetrahydro-2lambda(6)-furo[3,4-d][1,3,2]dioxathiol-4-yl]methyl 4-methylbenzoate[(2S,4R,5S)-4-hydroxy-5-methoxytetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S,5S)-4-fluoro-5-methoxytetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S,5S)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl 4-methylbenzoate6-chloro-9-(trimethylsilyl)-9H-purine[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl 4-methylbenzoate6-chloropurine riboside; (2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol1-[(chlorocarbothioyl)oxy]benzene; Phenylchlorothioformate(2R,3S,4R,5R)-5-(6-chloro-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydro-3-furanyl benzoate(2R,3S,4R,5R)-5-(6-chloro-9H-purin-9-yl)-4-hydroxy-2-[(trityloxy)methyl]tetrahydro-3-furanyl benzoate(2R,3R,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluoro-2-[(trityloxy)methyl]tetrahydro-3-furanyl benzoate(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-[(trityloxy)methyl]tetrahydro-3-furanolO-[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-[(trityloxy)methyl]tetrahydro-3-furanyl] O-phenyl carbonothioate9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine6-chloropurine riboside; (2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol1-[(chlorocarbothioyl)oxy]benzene; Phenylchlorothioformate(2R,3S,4R,5R)-5-(6-chloro-9H-purin-9-yl)-4-hydroxy-2-[(trityloxy)methyl]tetrahydro-3-furanyl benzoate(2R,3R,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluoro-2-[(trityloxy)methyl]tetrahydro-3-furanyl benzoateO-[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-[(trityloxy)methyl]tetrahydro-3-furanyl] O-phenyl carbonothioateO-[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-[(trityloxy)methyl]tetrahydro-3-furanyl] O-phenyl carbonothioate9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine(2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-[(trityloxy)methyl]tetrahydro-3,4-furandiol(2R,3R,4R,5R)-5-(6-chloro-9H-purin-9-yl)-4-[[(trifluoromethyl)sulfonyl]oxy]-2-[(trityloxy)methyl]tetrahydro-3-furanyl benzoate9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine(2R,3R,5S)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3-furanol(2R,3R,5S)-2-(6-chloro-9H-purin-9-yl)-5-[(trityloxy)methyl]tetrahydro-3-furanol[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl trityl ether; 6-chloro-9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purineN-(9H-Purin-6-yl)benzamide; N6-Benzoyladeninep-Toluoyl chloride; 4-methylbenzoyl chloride(5S)-3-fluoro-5-(hydroxymethyl)-2(5H)-furanone[(2S)-4-fluoro-5-oxo-2,5-dihydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S)-4-fluoro-5-oxotetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S)-4-fluoro-5-hydroxytetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S,5R)-5-(acetoxy)-4-fluorotetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S,5R)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S,5R)-5-[6-(benzoylamino)-9H-purin-9-yl]-4-fluorotetrahydro-2-furanyl]methyl 4-methylbenzoate[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methanol9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one(2R,3R,5S)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3-furanol(2R,3R,5S)-2-(6-chloro-9H-purin-9-yl)-5-[(trityloxy)methyl]tetrahydro-3-furanol[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl trityl ether; 6-chloro-9-[(2R,3S,5S)-3-fluoro-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purine[(2R,3S,4S,5R)-4-(acetyloxy)-3-bromo-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydro-2-furanyl]methyl acetate(2R,3R,5S)-5-[(acetyloxy)methyl]-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydro-3-furanyl acetate[(2S,4R,5R)-4-(acetyloxy)-5-(6-chloro-9H-purin-9-yl)tetrahydro-2-furanyl]methyl acetate9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one[(2R,3S,4S,5R)-4-(acetyloxy)-3-bromo-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydro-2-furanyl]methyl acetate(2R,3R,5S)-5-[(acetyloxy)methyl]-2-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydro-3-furanyl acetate[(2S,4R,5R)-4-(acetyloxy)-5-(6-chloro-9H-purin-9-yl)tetrahydro-2-furanyl]methyl acetate[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methyl acetate[(2S,4R,5R)-5-(6-chloro-9H-purin-9-yl)-4-hydroxytetrahydro-2-furanyl]methyl acetate(5S)-5-(Hydroxymethyl)dihydro-2(3H)-furanone; (S)-(+)-Dihydro-5-(hydroxymethyl)-2(3h)-furanone(5S)-5-([[tert-Butyl(diphenyl)silyl]oxy]methyl)dihydro-2(3H)-furanone[(2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydro-2-furanyl]methanol6-chloro-9-(trimethylsilyl)-9H-purine(3R,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-hydroxydihydro-2(3H)-furanone(3S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-fluorodihydro-2(3H)-furanone(3S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-fluorotetrahydro-2-furanol(2R,3S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-fluorotetrahydro-2-furanyl acetate[(2S,4S,5R)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl tert-butyl(diphenyl)silyl ether; {[(2S,4S,5R)-5-bromo-4-fluorotetrahydro-2-furanyl]methoxy}(tert-butyl)diphenylsilane9-[(2R,3S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-fluorotetrahydro-2-furanyl]-9H-purin-6-amine; 9-[(2R,3S,5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-fluorotetrahydro-2-furanyl]-9H-purin-6-ylamine
