上游原料
2,5-Furandione; Maleic anhydride(2R)-2-Amino-2-(2-methoxy-6-methylphenyl)-1-ethanol(Z)-4-[[(1R)-2-Hydroxy-1-(2-methoxy-6-methylphenyl)ethyl]amino]-4-oxo-2-butenoic acid1-[(1R)-2-Hydroxy-1-(2-methoxy-6-methylphenyl)ethyl]-1H-pyrrole-2,5-dione5-[(1R)-2-Hydroxy-1-(2-methoxy-6-methylphenyl)ethyl]-1-methyl-3a,6a-dihydropyrrolo[3,4-d][1,2,3]triazole-4,6(1H,5H)-dione3-[(1R)-2-Hydroxy-1-(2-methoxy-6-methylphenyl)ethyl]-6-methyl-3,6-diazabicyclo[3.1.0]hexane-2,4-dione(1R)-4-Acryloyl-10,10-dimethyl-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione(1R)-4-([(1S,5S,6R)-3-[(1R)-2-Hydroxy-1-(2-methoxy-6-methylphenyl)ethyl]-8-methyl-2,4-dioxo-3,8-diazabicyclo[3.2.1]oct-6-yl]carbonyl)-10,10-dimethyl-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione(1R)-4-([(1S,5S,6R)-3-[(1R)-2-(Methoxymethoxy)-1-(2-methoxy-6-methylphenyl)ethyl]-8-methyl-2,4-dioxo-3,8-diazabicyclo[3.2.1]oct-6-yl]carbonyl)-10,10-dimethyl-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione(1R)-4-([(1S,5S,6R)-3-[(1R)-1-[2-(Bromomethyl)-6-methoxyphenyl]-2-(methoxymethoxy)ethyl]-8-methyl-2,4-dioxo-3,8-diazabicyclo[3.2.1]oct-6-yl]carbonyl)-10,10-dimethyl-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione[2-[(1R)-1-((1S,5S,6R)-6-[[(1R)-10,10-Dimethyl-3,3-dioxo-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]dec-4-yl]carbonyl]-8-methyl-2,4-dioxo-3,8-diazabicyclo[3.2.1]oct-3-yl)-2-(methoxymethoxy)ethyl]-3-methoxybenzyl](triphenyl)phosphonium bromide(1R)-4-([(1S,10R,13S,15R)-8-Methoxy-10-[(methoxymethoxy)methyl]-16-methyl-12-oxo-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-2,4,6,8-tetraen-15-yl]carbonyl)-10,10-dimethyl-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione(1R)-4-([(1S,2S,10R,13S,15R)-8-Methoxy-10-[(methoxymethoxy)methyl]-16-methyl-12-oxo-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-trien-15-yl]carbonyl)-10,10-dimethyl-3lambda(6)-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione(1S,2S,10R,13S,15R)-8-Methoxy-10-[(methoxymethoxy)methyl]-16-methyl-12-oxo-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-triene-15-carboxylic acid(1S,2S,10R,13S,15R)-10-(Hydroxymethyl)-8-methoxy-16-methyl-12-oxo-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-triene-15-carboxylic acid2-Bromo-1-methoxy-3-methylbenzene; 2-Bromo-3-methylphenyl methyl ether(4R,5S)-5-[(Benzyloxy)methyl]-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde(4R,5S)-5-[(Benzyloxy)methyl]-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde[(4R,5S)-5-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl](2-methoxy-6-methylphenyl)methanone[(4R,5S)-5-[(Methoxymethoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl](2-methoxy-6-methylphenyl)methanonebenzyl (2R,3R,5S)-5-[(benzyloxy)methyl]-2-formyl-3-[(methoxymethoxy)methyl]tetrahydro-1H-pyrrole-1-carboxylatebenzyl (2R,3R,5S)-5-[(benzyloxy)methyl]-2-[2-[3-methoxy-2-([(4R,5S)-5-[(methoxymethoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]carbonyl)phenyl]acetyl]-3-[(methoxymethoxy)methyl]-1-pyrrolidinecarboxylatebenzyl (2R,3R,5S)-5-[(benzyloxy)methyl]-2-(8-methoxy-1-[(4S,5S)-5-[(methoxymethoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-3-isoquinolinyl)-3-[(methoxymethoxy)methyl]-1-pyrrolidinecarboxylatebenzyl (2R,3R,5S)-5-[(benzyloxy)methyl]-2-((1R,3S)-8-methoxy-1-[(4S,5S)-5-[(methoxymethoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-1,2,3,4-tetrahydro-3-isoquinolinyl)-3-[(methoxymethoxy)methyl]-1-pyrrolidinecarboxylate2,2,2-trichloroethyl (1R,3S)-3-[(2R,3R,5S)-1-[(benzyloxy)carbonyl]-5-[(benzyloxy)methyl]-3-[(methoxymethoxy)methyl]pyrrolidinyl]-8-methoxy-1-[(4S,5S)-5-[(methoxymethoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate2,2,2-trichloroethyl (1R,3S)-3-[(2R,3R,5S)-1-[(benzyloxy)carbonyl]-5-[(benzyloxy)methyl]-3-[(methoxymethoxy)methyl]pyrrolidinyl]-8-methoxy-1-[(4S,5S)-5-[(methoxymethoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate2,2,2-trichloroethyl (1R,3S)-3-[(2R,3R,5S)-1-[(benzyloxy)carbonyl]-5-[(benzyloxy)methyl]-3-[(methoxymethoxy)methyl]pyrrolidinyl]-1-[(1S,2S)-1,2-dihydroxy-3-(methoxymethoxy)propyl]-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate2,2,2-trichloroethyl (1R,3S)-3-[(2R,3R,5S)-1-[(benzyloxy)carbonyl]-5-[(benzyloxy)methyl]-3-[(methoxymethoxy)methyl]pyrrolidinyl]-1-(hydroxymethyl)-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate2,2,2-trichloroethyl (1R,3S)-1-[(acetoxy)methyl]-3-[(2R,3R,5S)-1-[(benzyloxy)carbonyl]-5-formyl-3-[(methoxymethoxy)methyl]pyrrolidinyl]-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylatebenzyl (1S,2S,10R,12S,13S,15R)-10-[(acetoxy)methyl]-12-hydroxy-8-methoxy-15-[(methoxymethoxy)methyl]-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-triene-16-carboxylatebenzyl (1S,2S,10R,12R,13S,15R)-10-[(acetoxy)methyl]-12-cyano-8-methoxy-15-[(methoxymethoxy)methyl]-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-triene-16-carboxylate[(1S,2S,10R,12R,13S,15R)-12-cyano-15-(hydroxymethyl)-8-methoxy-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-trien-10-yl]methyl acetate[(1S,2S,10R,12R,13S,15R)-12-cyano-15-(hydroxymethyl)-8-methoxy-16-methyl-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-trien-10-yl]methyl acetate(1S,2S,10R,12R,13S,15R)-10-[(Acetoxy)methyl]-12-cyano-8-methoxy-16-methyl-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-triene-15-carboxylic acid(1S,2S,10R,12R,13S,15R)-12-Cyano-10-(hydroxymethyl)-8-methoxy-16-methyl-11,16-diazatetracyclo[11.2.1.0(2,11).0(4,9)]hexadeca-4,6,8-triene-15-carboxylic acid
