| 药品名称 |
Ceftizoxime
|
| 分子靶点 |
MecA PBP2' (penicillin binding protein 2');Penicillin-binding protein 1A;Penicillin-binding protein 1B;Peptidoglycan synthase FtsI
|
| 药物类型 |
Small Molecule
|
| 研发阶段 |
Approved, Investigational
|
| 药物描述 |
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
|
| 结构式 |
 |
| 药物别名 |
7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Ceftizoxima;Ceftizoxime;Ceftizoximum;syn-7-(2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acid
|
| 治疗类别 |
Amides;Anti-Bacterial Agents;Anti-Infective Agents;Antibacterials for Systemic Use;Antiinfectives for Systemic Use;Aza Compounds;Azabicyclo Compounds;beta-Lactams;Cefotaxime;Cephacetrile;Cephalosporins;Lactams;Nephrotoxic agents;OAT3/SLC22A8 Inhibitors;OAT3/SLC22A8 Substrates;Sulfur Compounds;Thiazines;Third-Generation Cephalosporins
|
| UNII号 |
C43C467DPE
|
| CAS号 |
68401-81-0
|
| 分子量 |
383.403
|
| 分子式 |
C13H13N5O5S2
|
| 适应症 |
For the treatment of infections due to susceptible strains of microorganisms.
|
| 药效学 |
Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
|
| 作用机制 |
Ceftizoxime is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae. Ceftizoxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that ceftizoxime interferes with an autolysin inhibitor.
|
| 分布量 |
The mean apparent volume of distribution ranges between 15 - 28L.
|
| 蛋白结合 |
30% protein-bound across the standard concentration range.
|
| 代谢 |
Ceftizoxime is not metabolized and is excreted virtually unchanged by the kidneys in 24 hours.
|
| 排泄 |
Excreted virtually unchanged by the kidneys in 24 hours.
|
| ATC代码 |
J01DD07
|
