| CAS号 | 119302-91-9 |
| 中文别名 | 罗库溴铵(肌松药); L-[(2Β,3Α,5Α,16Β,17Β)-17-(乙酰氧基)-3-羟基-2-(4-吗啉基)雄甾-16-基]-1-丙烯基吡咯铵溴化物 |
| 英文别名 | [3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate bromide; ROCURONIUN BROMIDE; 1-[(2b,3a,5a,16b,17b)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide; Esmeron; Org-9426; Zemuron; Rocuronium Bromide／1-[17B-(acetyloxy)-3a-hydroxy2B-(4-morpholinyl)-5a-androstan-16B-yl]-1-(2-propenyl)pyrrolidinium bromide; [3-Hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate bromide; 1-[17B-(acetyloxy)-3a-hydroxy2B-(4-morpholinyl)-5a -androstan-16B-yl]-1-(2-propenyl)pyrrolidinium bromide; 1-[17B-(acetyloxy)-3a-hydroxy-2B-(4-morpholinyl)-; 1-[(2,3a,5a,16,17)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide; 1-[(2β，3α，5α，16β，17β)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)andrcstan-16-y1]-1-propenylpyrrolidinium bromide; Esmeron：Zemuron; Eslax |
| 分子量 | 609.69 |
| 分子式 | C32H53N2O4.BR |
| EINECS编号 |
综合信息
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罗库溴铵的物理化学性质
【溶解性】在乙醇中极易溶解，在水中易溶，在乙醚中几乎不溶。
【外观】白色或类白色结晶性粉末至微黄白色粉末。有吸湿性，无臭，味苦。
【熔点】162-1640C
罗库溴铵的产品用途
【用途一】肌肉松弛药。非去极化神经肌肉阻断剂。用于住院和门诊患者全身麻醉和常规气管插管时的辅助用药，能使手术和机械换气期间骨骼肌肉松弛。
应用领域
上下游产品信息
化学品安全说明书(MSDS)
储运特性
罗库溴铵的制备方法
【方法一】(2α，3α，5α，16α，17β)-2，3，16，17-二环氧雄甾-17-醇乙酸酯(I)和四氢吡咯水溶液回流1h，得到的17-酮(Ⅱ)和硼氢化钠，在甲醇中搅拌，还原得到化合物(Ⅲ)。和吗啡水溶液回流3d，得到化合物(Ⅳ)。部分乙酰化，再和烯丙基溴反应，即得产物。
安全术语
风险术语
上游原料
MorpholinePyrrolidine3-Bromo-1-propene; 3-Bromopropene；allyl bromide(1aR,2aS,2bS,4aS,5aR,6aS,6bR,8aS,9aS)-2a,4a-dimethylhexadecahydro-4bH-oxireno[2'',3'':4',5']cyclopenta[1',2':7,8]phenanthro[2,3-b]oxiren-4-yl acetate(1R,2S,3aS,3bR,5aS,6aS,7aR,8aS,8bS,10aS)-8a,10a-Dimethyl-2-(1-pyrrolidinyl)hexadecahydro-1H-cyclopenta[7,8]phenanthro[2,3-b]oxiren-1-ol(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-10,13-Dimethyl-2-(4-morpholinyl)-16-(1-pyrrolidinyl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-(4-morpholinyl)-16-(1-pyrrolidinyl)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
