| CAS号 | 104227-87-4 |
| 中文别名 | 2-[2-(2-氨基-9H-嘌呤-9-基)乙基]-1,3-丙二醇二乙酸酯 |
| 英文别名 | [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate; FAMCICLOVIR; famcyclovir; Famciclover; Amciclovir FAMCICLOVIR, MORPURE HPLC PURIFIED, DELIVERED >= 98% PURE WITH HPLC UV CHROMATOGRAM; FAMCICLOVER 98.5+% USP; 2-(acetoxymethyl)-4-(2-amino-4,5-dihydro-9H-purin-; 2-[2-(2-AMINO-9H-PURIN-9-YL)ETHYL]-1,3-PROPANEDIOL(FAMCICLOVIR); 2-[2-(2-Amino-9H-purin-9-y1)ethyl]-1，3-propanediol diacetate(ester); BRL-42810; Famvir; FCV 1,3-Propanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, diacetate (ester); 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate; Diacetic acid 2-[2-(2-amino-9H-purine-9-yl)ethyl]-1,3-propanediyl ester; Diacetic acid 3-(2-amino-9H-purine-9-yl)propylidenebis(methylene) ester |
| 分子量 | 321.33 |
| 分子式 | C14H19N5O4 |
| EINECS编号 |
综合信息
查看供应
泛昔洛韦物理化学性质
外观：白色或类白色结晶性粉末
熔点：102-104°C
水溶解性：不溶
泛昔洛韦应用领域
用途一：抗病毒药，用于治疗带状疱疹和生殖器疱
用途二：抗病毒病。用于治疗急性带状疱疹。
用途三：抗感染药。
泛昔洛韦制备方法
方法1：0.5mol 2-氨基-6-氯嘌呤溶于含50g氢氧化钠的500ml水中，在10g钯-炭存在下，于0.7MPa氢压和50℃氢化3h，得到83%收率的2-氨基嘌呤。2-氨基嘌呤、2-(2-碘乙基)丙二醇二乙酯和碳酸钾在二甲基甲酰胺中，在室温下搅拌18h，得58％收率的泛昔洛韦。方法2：2-(2-碘乙基)丙二醇二乙酸酯、2-氨基-6-碘嘌呤和碳酸钾在二甲基甲酰胺中，搅拌18h，得到79.4%收率的化合物(I)，再在钯-炭催化下，于乙醇中氢化还原得到泛昔洛韦。
方法3：22.5g鸟嘌呤、88g三乙基甲基氯化铵和氯化亚砜，在50～70℃下缓慢搅拌0.5h，再于70℃下保持0.5h，得到28.5g 8-氯鸟嘌呤，其中含14.1%的水。将8-氯鸟嘌呤转化为盐酸盐，并在五氯化二磷存在下干燥。往该盐酸盐(2.04g)中加入6.6g三乙基甲基氯化铵在1lml乙腈的溶液，加入5.6ml三氯氧磷，在60℃下加热1h，得到1.78g 2-氨基-6，8-二氯嘌呤。5.8g 2-氨基-6，8-二氯嘌呤、9.4g 2-(2-碘乙基)丙二醇二乙酸酯和5.9g碳酸钾在100ml二甲基甲酰胺中，在室温下搅拌过夜，得到4.7g化合物(Ⅱ)。3.9g化合物(Ⅱ)在5%钯-炭存在下，以0.35MPa的氢压氢化还原，得到2.4g泛昔洛韦。
安全术语
风险术语
上游原料
6,8-Dichloro-9H-purin-2-ylamine; 6,8-Dichloro-9H-purin-2-aminedimethyl 3-(2-iodoethyl)pentanedioate2-[(acetoxy)methyl]-4-(2-amino-6,8-dichloro-9H-purin-9-yl)butyl acetate6,6-Dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione5-[2-(2-amino-6,8-dichloro-9H-purin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione5-[2-(2-amino-9H-purin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dionedimethyl 2-[2-(2-amino-9H-purin-9-yl)ethyl]malonate2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine5-[2-(2-Amino-6-chloro-9H-purin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dionetriethyl 3-bromo-1,1,1-propanetricarboxylatetriethyl 3-(2-amino-6-chloro-9H-purin-9-yl)-1,1,1-propanetricarboxylatetriethyl 3-(2-amino-9H-purin-9-yl)-1,1,1-propanetricarboxylatediethyl 2-[2-(2-amino-9H-purin-9-yl)ethyl]malonate6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurinetriethyl 3-bromo-1,1,1-propanetricarboxylatetriethyl 3-(2-amino-6-chloro-9H-purin-9-yl)-1,1,1-propanetricarboxylatedimethyl 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]malonate4-(2-amino-6-chloro-9H-purin-9-yl)-2-[[(methoxycarbonyl)oxy]methyl]butyl methyl carbonate2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurinebromo(vinyl)magnesium2,2-dimethyl-1,3-dioxan-5-one 2,2-dimethyl-5-vinyl-1,3-dioxan-5-yl methyl carbonate6-chloro-7-[2-(2,2-dimethyl-1,3-dioxan-5-ylidene)ethyl]-7H-purin-2-ylamine; 6-chloro-7-[2-(2,2-dimethyl-1,3-dioxan-5-ylidene)ethyl]-7H-purin-2-amine6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-ylidene)ethyl]-9H-purin-2-ylamine; 6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-ylidene)ethyl]-9H-purin-2-amine9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-9H-purin-2-amine; 9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl]-9H-purin-2-ylamine
